Of these, 10 of the top 17 pathways are known to be relevant to AD, including the top three overall pathways: senescence, TGF-β signaling, and epithelial adherens junction signaling (Figure 7G) (Caraci et al., 2018; Pearson et al., 2020; Saez-Atienzar and Masliah, 2020). The gene discussed is TGFB1; the disease is Alzheimer disease.