MAPT and Alzheimer disease: We further showed that while the ratio of CSF Aβ42:total-Tau (clinical markers for AD diagnosis (Maddalena et al., 2003)) predicted MCI with AUC of 0.758, Aβ42:total-Tau plus the five miRNAs improved the AUC to 0.813 (Sandau et al., 2020b).