So far, a few novel lncRNAs, including NEAT-1, LINC01714, HOXD-AS1, HOTTIP, LINC00665, and lnc-PKD2-2-3, have been revealed to modulate chemoresistance in CCA (Figure 2) (Lu et al., 2021; Qiu et al., 2019; Li et al., 2020b; Gao et al., 2021; Parasramka et al., 2017; Shen et al., 2020). This evidence concerns the gene HAGLR and cholangiocarcinoma.