Oxidative stress-induced lncRNA HULC, along with H19, increased the level of inflammatory mediators IL-6 and CXCR4, which in turn activated the positive feedback pathway of inflammation, promoting tumorigenesis in CCA via working as a sponge of miR-372/miR-373 and let-7a/let-7b, respectively (Wang et al., 2016). The gene discussed is H19; the disease is cholangiocarcinoma.