The three ferroptosis-related genes, including lipid the metabolism gene (ACACA) and energy metabolism genes (G6PD, SLC1A5), were also upregulated and correlated with poor prognosis in HCC patients (Lu et al., 2018; Lally et al., 2019; Liang et al., 2020). The gene discussed is ACACA; the disease is hepatocellular carcinoma.