Given Syt1’s indispensable role in vesicle recycling, and recent studies that implicate Syt1 in neurodegenerative disease (Brinkmalm et al., 2014; Gautam et al., 2015; Shi et al., 2020), this previously unknown interaction between DGKθ and Syt1 strengthens the notion that lipid-metabolizing enzymes are important regulators of neurotransmission. Here, SYT1 is linked to neurodegenerative disease.