An acidic microenvironment caused by lactic acid accumulation can cause the development of local tumor vascularization by stimulating vascular endothelial cell growth factor (VEGF) and interleukin-8 (IL-8)-mediated angiogenesis, increased tumor cell proliferation associated with decreased apoptosis, cell invasion, and metastasis [16]. The gene discussed is CXCL8; the disease is neoplasm.