IL17A and Stroke: Interestingly, in animal models of stroke, wild-type mice fare worse than immune-deficient mice, and IFN-γ and IL-17 have been identified as key players in T cell-mediated tissue damage (Yilmaz et al., 2006; Shichita et al., 2009; Gelderblom et al., 2012; Selvaraj and Stowe, 2017 The long-term effects of adaptive immune cell influx into the brain following stroke remain an active area of research.