For S22 population, in five overlapping ROHs between BFT and LMP, three genes were related to lipid metabolism (CRH), fatty acid composition (CYP7B1), and obesity (TLR4); two genes (PITX1 and ARPP21) were associated with muscle development; and four genes were involved in spermatogenesis (CATSPER3, PPP2CA and UBE2B) and embryonic development (SOX11). The gene discussed is ARPP21; the disease is obesity due to melanocortin 4 receptor deficiency.