SV2A PET was used to evaluate changes of synaptic density in damaged brain tissue after ischemic stroke, resulting in a decrease of SV2A density in the lesioned area compared to healthy controls and in a lower [11C]UCB-J signal in the non-lesioned regions of the affected hemisphere compared to the unaffected one (Michiels et al., 2021b). The gene discussed is SV2A; the disease is ischemic stroke.