Wilson et al. (2020) investigated possible correlations between mitochondrial, endoplasmic reticulum and synaptic dysfunctions in early drug-naïve Parkinson’s patients using PET tracers for mitochondrial complex 1, sigma 1 receptor and SV2A, with [18F]-BCPP-EF, [11C]-SA-4503, and [11C]UCB-J, respectively (Wilson et al., 2020). This evidence concerns the gene SV2A and Parkinson disease.