Nonetheless, CSF NfL is significantly increased in AD compared to controls, and predicts progression from MCI to AD (Sjögren et al., 2001; Petzold et al., 2007; Mattsson et al., 2016; Olsson et al., 2016; Zetterberg et al., 2016; Lista et al., 2017). The gene discussed is NEFL; the disease is Alzheimer disease.