MAPT and Alzheimer disease: Furthermore, there is growing evidence in favour of alternative hypotheses which place other proteins or processes, such as tau and neuroinflammation, as the central initiating mechanisms of AD pathogenesis (Alvarez A. et al., 1999; Alvarez R. et al., 1999; Ittner and Götz, 2011; Guzman-Martinez et al., 2019).