The soluble version and the IBs format of T22-GFP-H6 have been tested for the selective interaction with CXCR4+ cells to target metastatic cells in a variety of cancer types as well as their performance as an antimicrobial agent due to the presence of the T22 peptide (polyphemusin) isolated from the hemocytes of horseshoe crabs (Céspedes et al., 2016; Falgàs et al., 2020a; Falgàs et al., 2020b; Céspedes et al., 2020; Serna et al., 2021). Here, CXCR4 is linked to cancer.