It was observed increased expression of a network of proteins that includes cell surface receptors, such as HER3_pY1289, VEGFR2, and PDL1, plus IGFR signaling mediator IRS1, and cell cycle modulator CMYC, in more than 90 HNSCC patient samples with FAT1 mutation. Here, FAT1 is linked to head and neck squamous cell carcinoma.