Previous reports found vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF) to play a primary role in angiogenesis in malignancies associated with BRCA mutations (as various angiogenic and remodeling factors in tumor neovascularization) and both VEGF and bFGF are also necessary for the proliferation of eCAs (21, 22). This evidence concerns the gene FGF2 and neoplasm.