However, in LUSC, SKCM, THYM, and STAD, CBX3 expression was negatively correlated with cytokine and chemokine signaling pathways, as well as several immune-related pathways, including graft-versus-host disease, natural killer cell-mediated cytotoxicity and B/T cell receptor signaling pathways (Figure 14B). Here, PPIB is linked to graft versus host disease.