With the primary aim to determine whether detection of ctDNA after CRT is associated with risk of tumor progression Azad et al. have analyzed by NGS 802 hot spots in 607 genes for Single nucleotide polymorphisms (SNPs) previously associated with esophageal adenocarcinoma or squamous cell carcinoma, including hot spots in LRP1B and TP53 frequently identified in HNSCC. The gene discussed is TP53; the disease is head and neck squamous cell carcinoma.