TP53 and esophageal squamous cell carcinoma: In the COSMIC database, there are to date 2,236 samples of ESCC genomic profiles reported, indicating that the most frequently mutated genes are TP53 (58%), KMT2D (18%), NOTCH1 (16%), LRP1B (14%), and FAT1 (14%), similar to HNSCC top 5 genes.