Wang et al. have investigated genomic alterations in TP53, CDKN2A, HRAS, NRAS, PIK3CA, and HPV16 DNA in plasma or saliva from 93 patients with HNSCC, documenting a potential role for diagnosis of invasive HNSCC for this gene panel (63). The gene discussed is HRAS; the disease is head and neck squamous cell carcinoma.