In immunocompetent subjects, MMP-1, MMP-9, and TIMP-1 expression associated with stromal macrophages in BCC (107) and TILs comprise CD4 + T-helper cells and FoxP3 + T-regulatory (Tregs); these immune cell populations can also be found in the peritumoral inflammatory infiltrates. Here, MMP1 is linked to skin basal cell carcinoma.