In BCC's stroma and the peritumoral area, CAFs can secrete an array of MMPs (e.g., MMP-1, MMP-2, MMP-3, MMP-9, MMP-11, MMP-13, MMP-14, MMP-19), all of them promoting ECM remodeling (105, 111) and favoring tumor escape from the anti-tumoral action of the immune cells (109). Here, MMP2 is linked to skin basal cell carcinoma.