CDK4 and colorectal carcinoma: Moreover, the combination of NVP-AUY922 and BBR induced cell growth arrest by suppressing cyclin-dependent kinase 4 (CDK4) expression and inducing miR-296-5p-mediated inhibition of the peptidylprolyl cis/trans isomerase NIMA-interacting 1 (Pin1)-β-catenin-cyclin D1 signaling pathway in CRC (129).