BECN1 and glioblastoma: Moreover, BBR has been suggested to induce autophagy in glioblastoma by targeting the AMP-activated protein kinase (AMPK)/mechanistic target of rapamycin (mTOR)/ULK1 pathway (116) and in liver cancer cells by stimulating the release of beclin-1 from the Bcl-2/beclin-1 complex (117).