Figure 3 shows that even though there were no significant differences in the densities of vWF+-vessels and αSMA+-arterioles in both the contralateral hemisphere and the IBZ, and the diameter of arterioles and the number of αSMA+-SMCs in the contralateral hemispheres between the ABCA1−B/−B and ABCA1fl/fl T2DM-stroke mice, ABCA1−B/−B-T2DM stroke mice exhibit decreased vessel perimeter in both the contralateral hemisphere and the IBZ, and decreased arteriole diameter and SMC number in the IBZ compared with ABCA1fl/fl-T2DM stroke mice (p < 0.05, n = 9/group). This evidence concerns the gene VWF and type 2 diabetes mellitus.