The immunohisto-chemical-staining and quantification data show that the ABCA−B/−B-T2DM stroke mice exhibit a significant decrease in the densities of axons, phosphorylated-neurofilament, and myelin in the WM-bundles of CC (Figure 4, p < 0.05, n = 9/group), and WB/RT-PCR assay show that the protein and mRNA level of MBP was decreased in the ischemic brain tissues (Figure 4, p < 0.05, n = 6/group) at 21 days after dMCAo compared with the ABCA1fl/fl-T2DM stroke mice. The gene discussed is MBP; the disease is stroke disorder.