To investigate the mechanism underlying L-4F treatment-induced neurorestoration in T2DM-stroke, the macrophage/microglial and monocyte infiltration was measured using the levels of ED-1 and MCP-1, and the inflammatory factor TLR-4 and anti-inflammatory factors IGF-1 and IGF-1Rβ were measured using WB and RT-PCR assay. The gene discussed is CCL2; the disease is Stroke.