Figure 2 shows that the density of albumin in the ischemic core area increased in ABCA1−B/−B-T2DM stroke mice, while the expression of Occludin and AQP-4 within or around blood vessels in both the contralateral and the IBZ area in the ABCA1−B/−B-T2DM stroke mice significantly decreased compared with the ABCA1fl/fl-T2DM stroke mice (p < 0.05, n = 9/group). The gene discussed is AQP4; the disease is Stroke.