Using the CMAP database, we used 19 hub immune genes (KMT2A, PTPN1, TFAP2C, TLR7, SMARCE1, KLRD1, LIFR, FZD1, FST, TGFB2, KLRC4, CYSLTR1, PIK3R1, BCAR1, TRIM36, CCR9, THBS1, NOD2, and C7) to forecast latent therapeutic medicines for CRSWNP. This evidence concerns the gene PTPN1 and chronic rhinosinusitis with nasal polyps.