The pathway, C-T-P, and C-T-M network analyses suggest that the principal active compounds of H. cuspidatus, including caffeic acid, luteolin, esculetin, methyl rosmarinate, and 8-hydroxycirsimaritin, play a critical role in the treatment of asthma by regulating multiple miRNAs, including miR-99a, miR-498, miR-33b, and miR-18a, that target mRNAs, including PI3K, JAK, MAPK1, EGFR, and ESR1, in the immune-inflammatory, oxidative stress, and various kinase activities and receptor-binding pathways. This evidence concerns the gene PIK3CA and asthma.