The chronic HBV carriers with HBsAg-positive and HBeAg-negative can also develop HCC and liver-associated mortality that are related to baseline age, sex, serum HBV-DNA copies, and alanine aminotransferase (ALT) level (Kumar et al., 2009; Trepo et al., 2014; Koffas et al., 2021). The gene discussed is GPT; the disease is hepatocellular carcinoma.