Accumulated evidence showed the critical role of follicular helper T (Tfh) cells with high expressions of immune checkpoint molecules including TIM-3 and PD-1 in viral infection, including chronic HBV infection (Ye et al., 2015; Vella et al., 2017; Zhuo et al., 2017; Crotty, 2019; Yan et al., 2020; Cui et al., 2021; Liu et al., 2022). Here, HAVCR2 is linked to viral infectious disease.