Another was that alteration of gut microbiota could damage the integrity of the intestinal epithelial barrier, change the intestinal permeability, and increase the lipopolysaccharide, a component of the cell wall of gram-negative bacteria in the intestinal tract, which entered circulation to cause an immune response, affected insulin signaling pathway, and thus promoted insulin resistance and obesity (Caricilli and Saad, 2014). The gene discussed is INS; the disease is Insulin resistance.