The p.I33N variant was found in a patient with recurrent bacterial infections, low IgG, IgA, and IgM, immune thrombocytopenia, autoimmune hepatitis, cutaneous vasculitis, increased TCRαβ DNT cells, and sensorineural hearing loss that was diagnosed as CVID (8). The gene discussed is CD40LG; the disease is autoimmune thrombocytopenic purpura.