AXL and familial pancreatic carcinoma: AXL inhibition in the Kras/cdKn2a mutated model (KIC) of pancreatic cancer was accompanied by a reduction in IL-7, CCL11, IL6, and IL-1ß levels, as well as a net reduction in F4/80+ tumor-associated macrophages expressing ARG1, a potent immunosuppressive enzyme (182).