TGFB1 and malignant colon neoplasm: Colon cancer immune subtype classification described the immune landscape according to the tumor and stromal compartments and summarized six immune subtypes: wound healing(C1), IFN-γ dominant(C2), inflammatory(C3), lymphocyte depleted(C4), immunologically quiet(C5) and TGF-β dominant(C6) (25, 26).