LPL and B-cell chronic lymphocytic leukemia: Among 4,458 MGUS patients, 17,505 population-based controls, and first-degree relatives of patients and controls a 2.8-fold risk of MGUS was observed in first-degree relatives of MGUS-patients, in addition to an increased risk of MM (RR 2.9), WM/LPL (RR 4.0), and chronic lymphocytic leukemia (CLL, RR 2.0), compared with relatives of controls (24).