In our case, H89 induced IFN-γ (a proinflammatory cytokine essentially secreted by TLs and NK cells) which can induce an antitumor effect, unlike proinflammatory cytokines released by, e.g., neutrophils or monocytes, involved in inflammatory bowel disease (IBD) (for review: 40). This evidence concerns the gene IFNG and inflammatory bowel disease.