Most markers of inflammation (e.g., interleukin 6 [IL-6], soluble tumor necrosis factor receptor 1, and high-sensitivity C-reactive protein [hs-CRP]), monocyte/macrophage activation (soluble CD14 [sCD14]), gut epithelial barrier dysfunction (fatty acid binding protein-2 [FABP-2]), and many others predict increased mortality during treated HIV infection, even among those with high current CD4+ T-cell counts (5). This evidence concerns the gene IL6 and HIV infectious disease.