In a mouse model of Pseudomonas aeruginosa-induced sepsis, the deficiency of Atg7 gene, an indispensable regulatory factor in inducing autophagy (132) through phagophore initiation, expansion, transition and fusion (130, 133), could enhance the activity of inflammasomes in macrophages via elevating blood levels of IL-1β and IL-18 and increasing macrophage pyroptosis (134). The gene discussed is IL18; the disease is Sepsis.