Through the using of PAD2-specific inhibitors, they demonstrate that it could decrease NETosis and macrophage’casepase-11-dependent pyroptosis, and inhibition of caspase-11 activation could lead to reduce the release of IL-1α and high mobility group box 1 (HMGB1) in the peritoneal cavity, which increases the number of macrophages, significantly reduces bacterial load and inflammation in the blood, and ultimately increases survival and organ function after sepsis (54). This evidence concerns the gene PADI2 and Sepsis.