found that the level of the caspase-1, the percentage of caspase-1-induced peripheral blood monocyte pyroptosis, and the level of IL-18 were significantly increased in patients with post-traumatic sepsis compared with healthy subjects, and the percentage of peripheral blood mononuclear cells pyroptosis could predict the development and the occurrence of post-traumatic sepsis (60). Here, IL18 is linked to Sepsis.