HMGB1 and Sepsis: manifested that in Ehrlichia-induced sepsis mice, caspase-11-mediated HMGB1 cytosolic translocation and extracellular secretion are linked to the induction of pyroptosis, the IFNAR signaling involve in this process, which played an essential role in bacterial replication and NKT cells, CD8+ cells and neutrophils expanded during this process, resulting the damage of liver in sepsis (57).