CARD9 and Sepsis: TREM-1-induced spleen tyrosine kinase (SYK) mobilization is responsible for microglial pyroptosis through CARD9/NF-κB and NLRP3/caspase-1 pathways both in vivo and in vitro. It is worth mentioning that such inflammation is not directly equivalent to sepsis, according to the definition of sepsis and their role in sepsis remains to be studied (68).