SKG mice harboring microbiota from RA patients had an increased number of intestinal Th17 cells and developed severe arthritis after zymosan treatment. In addition, naive SKG mouse T cells co-cultured with P. copri -challenged dendritic cells produced IL-17 in response to RPL23A antigen and rapidly induced arthritis in mice (90). This evidence concerns the gene RPL23A and arthritic joint disease.