Likewise, DRB1*04:01-restricted T cells targeting β2-glycoprotein I (β2GPI) epitopes in patients with anti-phospholipid syndrome (APS) have been shown to cross-react with a bacterial peptide from R. intestinalis, inducing pro-inflammatory Th1 cell responses in vitro (51). The gene discussed is APOH; the disease is autoimmune polyendocrinopathy.