IGHE and type 2 diabetes mellitus: Longitudinal analysis has shown an immune dysregulation in Covid-19 patients and people with T2DM contracting Covid-19 infection had higher innate immune cells, lower T lymphocytes, a sustained increase in antiviral, anti-fungal response, and higher type 2 response such as IL-5, IL-13, IgE, and eosinophils (8).