Indeed, while both NOD.H2h4.IL-17-/- and NOD.H2h4 IFN-γR-/- mice are resistant to thyroiditis, depletion of CD25+ Tregs induces thyroiditis in NOD.H2h4.IL-17-/- mice but not in NOD.H2h4 IFN-γR-/- mice (50). Here, IFNGR1 is linked to thyroid gland disorder.