Moreover, NOD.H2h4-IFN-γ-/-, NOD.H2h4-IFN-γR-/-, and NOD.H2h4-IL-17-/- are resistant to the development of thyroiditis (48, 49), suggesting that both Th1 and Th17 profiles contribute to the pathology (50). Here, IL17A is linked to thyroid gland disorder.