More recently, Inderberg’s group isolated a human telomerase reverse transcriptase (hTERT)-specific TCR was identified in a CD4 T-cell clone from a vaccinated pancreatic cancer patient that, when expressed in primary CD4 and CD8 T cells, conveyed potent killing efficacy and reduced tumour growth, leading to improved survival in a xenograft mouse model (143). This evidence concerns the gene CD4 and familial pancreatic carcinoma.