NLRP12 functions as a negative regulator of noncanonical NF-κB signaling, making Nlrp12-/- mice more susceptible to gastrointestinal inflammation in the context of inflammatory bowel disease, colitis-associated cancer, and obesity as shown in previous studies (28, 34, 38, 49, 59). This evidence concerns the gene NFKB1 and obesity due to melanocortin 4 receptor deficiency.