TGM2 and cranioectodermal dysplasia: Translocating to the lamina propria of the small intestine, type 2 transglutaminase (TG2), a CeD autoantigen, deamidates partially-digested gluten peptides, causing TG2 to autocatalyze itself and increasing the affinity of gluten peptides to DQ2/8 to antigen presenting cells, thus inducing T-cell driven auto-destruction of small intestinal epithelia (10).