Activations of the NLRP3 inflammasome and CD133 in GBM tumor cells could induce the production of IL-1β and its downstream chemokines CCL3, CXCL3, and CXCL5 (57), which facilitate the migration, proliferation, self-renewal, and invasion of GBM (58–60). Here, CXCL5 is linked to glioblastoma.