And then, M2 GAMs also release IL-1β that activates protein kinase c (PKC)-delta and mediates phosphorylation of the glycolytic enzyme glycerol-3-phosphate dehydrogenase (3-PGDH), which subsequently activates phosphatidylinositol-3-kinase (PI3K) and promotes a feed-forward inflammatory loop in GBM tumor cells (68, 90). The gene discussed is IL1B; the disease is glioblastoma.