Specially, the demethylase activity of ALKBH5 has been demonstrated as an indispensable role in regulating the conditions of hypoxia and inflammatory TME in GBM and is required for NLRP3 inflammasome-related CXCL8 and NEAT1 gene activation (24, 113, 114). The gene discussed is CXCL8; the disease is glioblastoma.