GBM patients with an unmethylated O6-methylguanine-DNA methyltransferase (MGMT) promoter significantly show an elevated expression of inflammatory genes such as IL-6, CCL2, CCXCL2, HLA-A, and Serum amyloid A1 (108, 109), similar to methylation of MGMT, positively associated with IL-6-mediated primary GBM procession (110). Here, CCL2 is linked to glioblastoma.