This implies that inflammation is associated with high expression of MGMT. Additionally, N6-methyladenine (N6-mA) is highly enriched in histone 3 lysine 9 trimethyl (H3K9me3) in GBM tumor cells, which is induced by ALKBH and exacerbates GSCs’ self-renewal and proliferation (111, 112). Here, MGMT is linked to neoplasm.