Interestingly, EZH2 inhibitors (MC4040 and MC4041) not only reverse the pro-inflammatory phenotype of GBM U-87 and GL-1 cells by downregulating the levels of H3K27me3, but also inhibit epithelial-mesenchymal transition and migration of primary GBM tumor cells by reducing the level of VEGF and VEGFR1, resulting in inhibiting GBM cell proliferation and invasion of GBM (96). The gene discussed is EZH2; the disease is neoplasm.