Represented by IL-1 and IL-6, primary mediators of GBM tumor cells in the inflammatory TME can orchestrate immunological activation and inflammatory signaling cascades such as hypoxia-inducible factor-1α (HIF-1α), Wnt-1, nuclear factor-kappa B (NF-κB), and STAT3 in GBM (52–55) (Figure 1). Here, STAT3 is linked to neoplasm.