Interestingly, IL-33 could transform non-stem cells to GBM stem cells (66), activate disintegrin and metalloproteinase with thrombospondin motifs 5 (ADAMTS5) and EGFR by promoting the accumulation of tenascin-C (TNC), which in turn exacerbates GBM tumor cell proliferation (47, 64, 65, 67). The gene discussed is TNC; the disease is glioblastoma.