Figure 1C shows the chromosomal positions with copy number variations of m6A regulators. In addition, to identify the relations between genetic variations and the expression of m6A regulators, we compared the mRNA expression levels of 32 m6A regulators between tumour and normal samples. The results suggested that the levels of METTL16 and FTO expression were reduced, while those of RBM15, NSUN2, YTHDF2, G3BP1 and HNRNPA2B1 were increased in tumour tissues (Figure 1D). Here, METTL16 is linked to neoplasm.