IL1B and brain injury: As evidenced by fetal ultrasound, the anti-inflammatory effects of carbetocin protect against the destructive effects of interleukin-1beta (IL-1β) and low protein diet (LPD) on myelination in the double hit rat fetus model of perinatal brain injury due to prematurity plus fetal growth restriction induced by administration of a low protein diet (LPD) during gestation and potentiated by postnatal injections of subliminal doses of IL-1β (105).