MAP3K5 and Hepatic fibrosis: New drugs for other targets have also been designed, including targeting C-C motif chemokine receptor (CCR)2-CCR5, apoptosis signaling protease-1 (ASK-1), glucagon-like peptide (GLP)-1 and etc. CCR2/5 improve liver fibrosis by activating inflammatory signals and immune cell infiltration, causing liver damage (128).