TTN and alcohol dependence: We combined the TCscore with other factors, including the mutation status of known oncogenes (e.g., TP53, ARID1A, AXIN1, CTNNB1, and TTN) and clinical characteristics (e.g., history of alcoholism, hepatitis B or C virus infection, expression of PDCD1, and tumor mutation burden), and plotted the Kaplan–Meier survival curves based on these parameters for cases from the TCGA database (Figure S11).