We combined the TCscore with other factors, including the mutation status of known oncogenes (e.g., TP53, ARID1A, AXIN1, CTNNB1, and TTN) and clinical characteristics (e.g., history of alcoholism, hepatitis B or C virus infection, expression of PDCD1, and tumor mutation burden), and plotted the Kaplan–Meier survival curves based on these parameters for cases from the TCGA database (Figure S11). The gene discussed is CTNNB1; the disease is alcohol dependence.