In a proteomic study of paired tumor and adjacent normal tissues, 159 cases of hepatitis B virus-related HCC were divided into subtypes with metabolic, proliferative, and tumor immune microenvironment (TIME) disorders, and PYCR2 and ADH1A were found to be differentially expressed and involved in metabolic reprogramming in the subtypes (7). This evidence concerns the gene ADH1A and neoplasm.