IL4R and helminthiasis: Here, injection of RA-attenuated larvae produced lower levels of IgG1 antibodies in serum IL-4Rα deficient mice (IL-4Rα-/-) on BALB/c background, but the serum from vaccinated wild-type BALB/c mice confers protection to IL-4Rα-/- mice, suggesting the Th2 antibodies is crucial for parasite elimination and resistance in BALB/c mice (97).Genetic differences due to a distinct pattern of cytokines secreted and markers expressed by myeloid cells can also correlate with different helminth infection outcomes.