EIF2AK3 and neurodegenerative disease: -in preclinical studies of neurodegenerative disease, prolonged overactivation of PERK/eIF2a-P signaling is followed by sustained attenuation of protein synthesis, leading to memory impairment and neuronal loss-Re-establishing translation rates by inhibition of eIF2a-P activity, genetically or pharmacologically, improves memory and prevents neurodegeneration and extends survival (66)