A more recent analysis of eosinophilia and elevated IgE in the USIDNET revealed that 3 out of 3 patients with NFKB2 defects had at least one atopic manifestation and eosinophilia above the upper limit of normal in the reference population and an increased proportion of patients with IKBKG defects had both eosinophilia and elevated IgE (68). This evidence concerns the gene IGHE and Increased total eosinophil count.