While the extent to which the atopic phenotypes observed in LOF mutations in the CBM complex are explained by disrupting downstream NF-κB signaling is not clear, a retrospective analysis of patients with IEI registered in the USIDNET revealed that more than half of patients with NF-κB Essential Modulator (NEMO, also known as IKBKG) deficiency were noted to have atopic dermatitis (67). Here, IKBKG is linked to atopic eczema.