A pathogenic PIM1 mutation (c.403G>A, p.Glu135Lys, heterozygous) was detected in a MYC/BCL2/BCL6 triple-hit DLBCL patient, and a pathogenic TP53 germline mutation (c.818G>A, p.R273H, heterozygous) was found in another DLBCL patient (5, 46). The gene discussed is PIM1; the disease is diffuse large B-cell lymphoma.