Further, IFN-γ was found to be amongst the most upregulated cytokines in COVID-19 patients, along with IL-6 and TNF-α; concomitant blockade of IFN-γ and TNF-α rescued mortality in k18-hACE2-Tg mice that were infected with SARS-CoV-2 (192). This evidence concerns the gene TNF and COVID-19.