We quantified 23 cytokines in peripheral blood serum after CAR-T cells infusion and found that the grade of CRS was positively correlated with six serum cytokines levels including G-CSF, IL-6, IL-8, IP-10, MIP-1a and RANTES (r2 = 0.468, p<0.001; r2 = 0.487, p<0.001; r2 = 0.679, p<0.001; r2 = 0.400, p<0.001; r2 = 0.467, p<0.001, r2 = 0.420, p=0.002) (Figure 2). The gene discussed is CCL5; the disease is congenital rubella syndrome.