Moreover, the peak levels of G-CSF (p=0.002), IL-6(p=0.008), IL-8(p=0.001), IP-10(p<0.001), MIP-1a (p=0.003)and RANTES(p<0.001)were significantly higher in patients with severe CRS compared to those with mild CRS (Figure 3). This evidence concerns the gene CXCL10 and congenital rubella syndrome.