Another study showed greater persistence of CD8 T cells expressing CD4-CD3ζ CARs at 1 year after multiple infusions when co-administered with CD4 T cells expressing CD4-CD3ζ CARs compared to CD8 CAR-T cells infused without CD4 CAR-T cells in identical twins (n=33) sero-different for HIV infection (87). This evidence concerns the gene CD4 and HIV infectious disease.