CD274 and neoplasm: Engineered CAR-T cells co-transduced with truncated PD-1 receptors lacking intracellular signalling functions which still bind PDL-1 but are unable to propagate inhibitory signals have been developed and demonstrated resistance to T cell exhaustion mediated by PDL-1 and prolonged survival in mice bearing xenograft tumours, compared with CAR T cells lacking these truncated PD-1 receptors (127).