It had been recently reported that the polymorphism of ADAMTS14 could have multiple effects, including joint effects of ADAMTS14 polymorphisms and environmental mutagens (smoking and betel nut chewing) leading to the tumorigenesis of oral cancer (18) and an involvement of ADAMTS14 polymorphisms in the progression of hepatocellular carcinoma (19). Here, ADAMTS14 is linked to hepatocellular carcinoma.