According to the threshold of the |NES| >1.5 and nominal p-value < 0.05, we identified five signaling pathways that showed significantly different enrichment in the ADAMTS14 expression phenotype, including INSULIN, MTOR, PPAR, renal cell carcinoma, and renin–angiotensin system pathways (Figure 5 and Table 3). The gene discussed is REN; the disease is hereditary clear cell renal cell carcinoma.