The Asian Cancer Research Group (ACRG) divided GC into 4 subtypes: microsatellite instability (MSI), mesenchymal transition (EMT), microsatellite stability/the tumor protein 53-active (MSS/TP53+), and microsatellite stability/the tumor protein 53-inactive (MSS/TP53−) (24). Here, TP53 is linked to cancer.