Meanwhile, the functions of these genes range from upstream cellular receptors, such as Toll-like receptor 1 (TLR1) and interleukin-17 receptor A (IL-17RA), to cytokines such as interleukin-1 β (IL-1β) and interleukin-6 (IL-6), to transcription factors such as CCAAT/enhancer binding protein β (CEBP β), and the roles of these genes in anti-arthritis were classified according to their biological functions (Supplementary Table 1). This evidence concerns the gene IL17RA and arthritic joint disease.