After adjusting for age, sex, and years of education, both the AD-RAI and APOE-ε4 status were associated with a lower MMSE score (APOE-ε4 status: β = -0.37, P = 0.003; AD-RAI: β = -0.76, P < 0.001), ADNI-EF score (APOE-ε4 status: β = -0.16, P = 0.008; AD-RAI: β = -0.39, P < 0.001), and ADNI-MEM score (APOE-ε4 status: β = -0.19, P = 0.023; AD-RAI: β = -0.42, P < 0.001). The gene discussed is APOE; the disease is Alzheimer disease.