SNCA and Parkinson disease: There are more than 20 reported genes associated with monogenic parkinsonism, including autosomal dominant SNCA encoding alpha-synuclein (αSyn) and LRRK2 encoding Leucine-rich repeat kinase 2, or autosomal recessive PRKN encoding the E3 ubiquitin ligase Parkin and PINK1 encoding Phosphatase and tensin homologue (PTEN)-induced kinase (Blauwendraat et al., 2020).